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Products
Pharmacology
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- Technical support
- Resources
Saralasin
Cat. No. NR-170
Structure:
Sar-Arg-Val-Tyr-Val-His-Pro-Ala-OH
Other Names:
[Sar1,Val5, Ala8] angiotensin II
Activity:
Angiotensin II receptor partial agonist
Saralasin, also known as [Sar1,Val5, Ala8] angiotensin II is an angiotensin II analog with substitutions to the angiotensin II sequence of sarcosine at position 1, valine at position 5,and alanine at position 8. Saralasin is a partial agonist of the angiotensin II receptor, and is used to treat hypertension.
Steinhausen et al (1986) Angiotensin II control of the renal microcirculation: effect of blockade by saralasin. Kidney Int. 30 56 PMID: 3747343
Thomas et al (1995) Saralasin suppresses arrhythmias in an isolated guinea-pig ventricular free wall model of simulated ischemia and reperfusion. J.Pharmacol.Exp.Ther. 274 1379 PMID: 7562511
Guimond et al (2014) Saralasin and Sarile Are AT2 Receptor Agonists. ACS Med. Chem. Lett. 5(10) 1129 PMID: 25313325
Related areas
All peptides >
All angiotensin receptor modulators >
All endocrinology research categories >
All cardiovascular research categories >
Technical Data
| Structure | Sar-Arg-Val-Tyr-Val-His-Pro-Ala-OH |
| CAS Number | 34273-10-4 |
| Molecular Weight | 912.0 |
| Formula | C42H65N13O10 |
| Sequence | XRVYVHPA |
| Modifications | X = Sarcosine |
Solubility and Storage
| Solubility | Soluble in dilute acid and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
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