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Angiotensin (1-7)
Cat. No. NR-160
Structure:
H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH
Activity:
Endogenous angiotensin peptide fragment
Angiotensin (1-7) is an endogenous peptide fragment and key component of the renin-angiotensin system (RAS). It is created from the conversion of angiotensin II (Ang II) into angiotensin (1–7) by angiotensin converting enzyme 2 (ACE2) and acts through activation of the non-AT1, non-AT2 receptor Mas. There are numerous examples of the effects of angiotensin (1–7) in the cardiovascular system where it counteracts the vasoconstrictive and proliferative effects of angiotensin II and also stimulates vasopressin release in vivo.
Santos et al (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc.Natl.Acad.Sci.U.S.A. 100 8258 PMID: 12829792
Santos (2014) Angiotensin-(1-7) Hypertension 63(6) 1138 PMID: 24664288
Patel et al (2016) Role of the ACE2/Angiotensin 1-7 Axis of the Renin-Angiotensin System in Heart Failure. Circulation Res. 118(8) 1313 PMID: 27081112
Related areas
All peptides >
All angiotensin receptor modulators >
All endocrinology research categories >
All cardiovascular research categories >
Technical Data
| Structure | H-Asp-Arg-Val-Tyr-Ile-His-Pro-OH |
| CAS Number | 51833-78-4 |
| Molecular Weight | 899.0 |
| Formula | C41H62N12O11 |
| Sequence | DRVYIHP |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store frozen, dark and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
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