The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Apelin 12
Cat. No. CS-020
Structure:
H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
Other Names:
A12
Activity:
C-terminal fragment of the 77 amino acid prepropeptide apelin
Apelin 12 (A12) is a biologically active C-terminal fragment of the 77 amino acid prepropeptide apelin, which is also the precursor of apelin 13 and apelin 36. Apelin 12 lowers blood pressure via a nitric oxide-dependent mechanism and is involved in control of feeding through stimulation of cholecystokinin (CCK) secretion. Apelin 12 can also reduce infarct size (IS) and augment contractile function recovery in the heart of rodents after regional or global ischemia.
Tatemoto et al (1998) Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor. Biochem. Biophys. Res. Commun. 251 (2) 471 PMID: 9792798
Pisarenko et al (2011) In vivo reduction of injury to the heart with apelin-12 peptide in rats. Bull. Exp. Biol. Med. 152(1) 79 PMID: 22803046
Pisarenko et al (2013) Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J. Pharmacol. Pharmacother. 4(3) 198 PMID: 23960425
Related areas
All peptides >
All apelin receptor modulators >
All cardiovascular research categories >
All appetite regulation research categories >
All neuroscience research categories >
Technical Data
| Structure | H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH |
| CAS Number | 229961-08-4 |
| Molecular Weight | 1422.7 |
| Formula | C64H103N21O14S |
| Sequence | RPRLSHKGPMPF |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store dessicated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Apelin 12 MSDS_613a349112b5d.pdf |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2025 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio