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Kisspeptin (zebrafish)
Cat. No. NR-070
Structure:
H-Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2
Other Names:
Zebrafish K10
Activity:
Zebrafish neuropeptide
Zebrafish (Danio rerio) possess two kisspeptins, kiss1 and kiss2 and their respective receptors (KissR1) and KissR2]. In the brain of zebrafish, Kiss2 is expressed in the preoptic-hypothalamic area, and Kiss1 is predominantly expressed in the habenula, an evolutionarily conserved epithalamic structure. KissR1 is expressed only in the habenula, while KissR2 is widely distributed in the brain, suggesting that the two kisspeptin systems play specific roles in there. The habenular Kiss1 is involved in the modulation of the raphe nuclei and serotonin-related behaviors such as fear response in the zebrafish.
Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843
Clarke et al (2015) Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders. Endocrinology and metabolism 30(2) 124 PMID: 26194072
Ogawa and Parhar (2018) Biological Significance of Kisspeptin-Kiss 1 Receptor Signaling in the Habenula of Teleost Species. Front. Endocrinol. 9 222 PMID: 29867758
Related areas
All peptides >
All kisspeptin receptor modulators >
All endocrinology research categories >
Technical Data
| Structure | H-Tyr-Asn-Leu-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2 |
| Molecular Weight | 1245.4 |
| Formula | C58H84N16O15 |
| Sequence | YNLNSFGLRY-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Kisspeptin (zebrafish) MSDS_602be3e7eb470.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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