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Kisspeptin 10 (rat, mouse)
Cat. No. NR-060
Structure:
H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2
Activity:
Endogenous peptide for the rodent kisspeptin receptor KISS1 (GPR54)
Kisspeptin-10 is the endogenous ligand for the rodent kisspeptin receptor (KISS1, GPR54) and is the minimal sequence of metastin (45-54) which activates GPR54 signaling. Kisspeptin has recently emerged as a key regulator of the mammalian reproductive axis while stimulation of GPR54 can also up-regulate proapoptotic genes which have tumour suppressor properties, inhibiting metastasis and invasion in mouse melanomas
Stafford et al (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res. 62 5399 PMID: 12359743
Navarro et al (2004) Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide. Endocrinology 145 4565 PMID: 15242985
Clarke et al (2015) Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders. Endocrinology and metabolism (Seoul, Korea) 30(2) 124 PMID: 26194072
Related areas
All peptides >
All kisspeptin receptor modulators >
All endocrinology research categories >
All cancer research categories >
Technical Data
| Structure | H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Tyr-NH2 |
| CAS Number | 478507-53-8 |
| Molecular Weight | 1318.5 |
| Formula | C63H83N17O15 |
| Sequence | H-YNWNSFGLRY-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Certificate of Analysis | NR-060 Kisspeptin 10 (rat, mouse) 0808A-190422 Product Datasheet_627ce3772a5eb.pdf |
| Safety Data Sheet | Kisspeptin 10 (rat, mouse) MSDS_602be4d2430ec.pdf |
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