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Products
Pharmacology
Type
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- Technical support
- Resources
Kisspeptin 10 (human)
Cat. No. NR-050
Structure:
H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
Other Names:
Metastin (45-54)
Activity:
Endogenous peptide for the kisspeptin receptor KISS1 (GPR54)
Kisspeptin 10 (human) is a potent endogenous ligand for the kisspeptin receptor (KISS1, GPR54). Kisspeptin 10 (human) binds with high affinity to rat and human KISS1 receptors, with Ki values of 1.59 and 2.33 nM respectively. Kisspeptin 10 (human) has recently emerged as a key regulator of the mammalian reproductive axis while stimulation of GPR54 can also up-regulate proapoptotic genes which have tumour suppressor properties, inhibiting metastasis and invasion in mouse melanomas
Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631 PMID: 11457843
Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326 677 PMID: 15596153
Clarke et al (2015) Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders. Endocrinology and metabolism (Seoul, Korea) 30(2) 124 PMID: 26194072
Guide to Pharmacology - Kisspeptin 10 (human)
Related areas
All peptides >
All kisspeptin receptor modulators >
All endocrinology research categories >
All cancer research categories >
Technical Data
| Structure | H-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| CAS Number | 374675-21-5 |
| Molecular Weight | 1302.5 |
| Formula | C63H83N17O14 |
| Sequence | YNWNSFGLRF-NH2 |
| Modifications | Amide at C terminal |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store frozen and desiccated in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Kisspeptin 10 (human) MSDS_602be457489c4.pdf |
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Recent citations
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