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Products
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- Technical support
- Resources
Bradykinin
Cat. No. PN-210
Structure:
H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
Activity:
Endogenous bradykinin receptor agonist
Bradykinin is the endogenous agonist for the bradykinin receptor and is a proinflammatory peptide. Bradykinin acts through two GPCRs, the B1 receptor, which is expressed as a result of tissue injury and has a role in chronic pain and inflammation, and the B2 receptor, which is constitutively expressed and is responsible for bradykinin's vasodilatory role. Bradykinin has selectivity for B2 over B1 receptors. In pain, bradykinin sensitises TRPV1 receptors.
Regoli et al (1998) Bradykinin receptors and their antagonists. Eur.J.Pharmacol. 348 1 PMID: 9650825
Leeb-Lundberg et al (2005) International union of pharmacology XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol.Rev. 57 27 PMID: 15734727
Abraham et al (2006) Peptide and non-peptide bradykinin receptor antagonists: role in allergic airway disease Eur.J.Pharmacol. 533 215 PMID: 16455073
Related areas
All peptides >
All bradykinin receptor modulators >
All TRP channel modulators >
All immunology research categories >
All pain research categories >
Technical Data
| Structure | H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH |
| CAS Number | 58-82-2 |
| Molecular Weight | 1060.22 |
| Formula | C50H73N15O11 |
| Sequence | RPPGFSPFR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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