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Products
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WaTx
Cat. No. PN-120
Structure:
H-Ala-Ser-Pro-Gln-Gln-Ala-Lys-Tyr-Cys-Tyr-Glu-Gln-Cys-Asn-Val-Asn-Lys-Val-Pro-Phe-Asp-Gln-Cys-Tyr-Gln-Met-Cys-Ser-Pro-Leu-Glu-Arg-Ser-OH (disulphide bridge between C9 and C27 and C13 and C23)
Other Names:
Wasabi receptor toxin
Activity:
Stabilizes the transient receptor potential cation channel 1 (TRPA1) in an active state
WaTx, also known as wasabi receptor toxin, is the active component of the venom of the Australian black rock scorpion Urodacus manicatus. WaTx targets the mechanical and chemical stress sensor transient receptor potential cation channel 1 (TRPA1), which it stabilizes in an active state characterized by prolonged channel openings and low Ca2+ permeability. WaTx elicits acute pain and pain hypersensitivity, but fails to trigger efferent release of neuropeptides and neurogenic inflammation typically produced by other toxins. WaTx is a unique pharmacological probe for dissecting TRPA1 function and its contribution to acute and persistent pain.
Lin King et al (2019) A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain Cell 178(6) 1362 PMID: 31447178
Related areas
All peptides >
All transient receptor potential channel modulators >
All pain research categories >
Technical Data
| Structure | H-Ala-Ser-Pro-Gln-Gln-Ala-Lys-Tyr-Cys-Tyr-Glu-Gln-Cys-Asn-Val-Asn-Lys-Val-Pro-Phe-Asp-Gln-Cys-Tyr-Gln-Met-Cys-Ser-Pro-Leu-Glu-Arg-Ser-OH (disulphide bridge between C9 and C27 and C13 and C23) |
| Molecular Weight | 3855.3 |
| Formula | C164H245N45O53S5 |
| Sequence | ASPQQAKYCYEQCNVNKVPFDQCYQMCSPLERS |
| Modifications | Disulphide bridges between cysteine 9 and cysteine 27 and cysteine 13 and cysteine 23 |
Solubility and Storage
| Solubility | Soluble in DMSO as stock. |
| Appearance | Freeze dried solid |
| Storage | Storage desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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