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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
BAM 22P
Cat. No. PN-110
Structure:
H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH
Activity:
Endogenous MRGPRX1 agonist
BAM 22P is a potent endogenous agonist, derived from the proenkephalin A gene, for the Mas-related G protein-coupled receptor X1 (MRGPRX1), which was originally isolated from bovine adrenal medulla. BAM 22P is a potent opioid agonist with an IC50 of 1.3 nM in guinea pig ileum. BAM 22P can produces opioid- and non-opioid receptor mediated antinociceptive effects in vivo.
Mizuno et al (1980) A new family of endogenous “big” met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity. Biochem. Biophys. Res. Comm. 97(4) 1283 PMID: 7213356
Hong et al (2004) Dual effects of intrathecal BAM22 on nociceptive responses in acute and persistent pain - potential function of a novel receptor. Br.J.Pharmacol. 141 423 PMID: 14718254
Solinski et al (2014) Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 66 570 PMID: 24867890
Related areas
All peptides >
All mas-related G protein-coupled receptor modulators >
All opioid receptor modulators >
All pain research categories >
Technical Data
| Structure | H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH |
| CAS Number | 76622-26-9 |
| Molecular Weight | 2839.2 |
| Formula | C130H184N38O31S2 |
| Sequence | YGGFMRRVGRPEWWMDYQKRYG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | BAM 22P MSDS_602ba930c514d.pdf |
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