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Products
Pharmacology
Type
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- Technical support
- Resources
TAT (47-57)
Cat. No. CP-070
Structure:
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH
Other Names:
HIV-1 Tat peptide, TAT (47-57) peptide fragment
Activity:
Cell penetrating peptide derived from the HIV transactivator protein (TAT)
TAT (47-57) is a widely used and well characterised cell penetrating fragment of the HIV transactivator protein (TAT). TAT (47-57) is an arginine-rich TAT peptide which penetrates plasma membrane through passive diffusion to deliver a large variety of cargoes, from small particles to proteins, nucleic acids, and liposomes.
Tréhin et al (2004) Metabolic cleavage of cell-penetrating peptides in contact with epithelial models: human calcitonin (hCT)-derived peptides, Tat(47-57) and penetratin(43-58). Biochem J. 382 (Pt 3) 945 PMID: 15193145
Ziegler and Seelig (2004) Interaction of the protein transduction domain of HIV-1 TAT with heparan sulfate: binding mechanism and thermodynamic parameters. Biophys J. 86 (1 Pt 1):254 PMID: 14695267
Jones et al (2005) Characterisation of cell-penetrating peptide-mediated peptide delivery. Br J Pharmacol. 145(8):1093 PMID: 15937518
Related areas
Technical Data
| Structure | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH |
| CAS Number | 191936-91-1 |
| Molecular Weight | 1558.95 |
| Formula | C64H118N32O14 |
| Sequence | YGRKKRRQRRR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry and frozen in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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