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Leptin-1
Cat. No. KS-350
Structure:
H-Lys-Gln-Lys-Val-Thr-Gly-Leu-Asp-Phe-Ile-Pro-Gly-Leu-His-Pro-Ile-Leu-NH2
Activity:
AMPK, PI3K and AKT activator
Leptin-1 is a peptide derived from the N-terminal of human leptin, which can improve glucose metabolism by increasing glucose uptake and GLUT4 expression, and its translocation to the plasma membrane. Leptin-1 induced glucose uptake is mediated through activation of AMPK, PI3K, and AKT, and exerts its metabolic effect through the activation of JAK2, an important downstream target of the leptin receptor. Leptin-1 increases mitochondrial biogenesis and ATP production, and increases expression of PGC1α, NRF1, and Tfam proteins. In a diabetic mouse model, leptin-1 significantly decreases blood glucose level and improves glucose tolerance.
Ali et al (2024) A peptide derived from the amino terminus of leptin improves glucose metabolism and energy homeostasis in myotubes and db/db mice. J Biol Chem. 300 12 107919 PMID: 39490585
Related areas
Technical Data
| Structure | H-Lys-Gln-Lys-Val-Thr-Gly-Leu-Asp-Phe-Ile-Pro-Gly-Leu-His-Pro-Ile-Leu-NH2 |
| Molecular Weight | 1874.11 |
| Formula | C89H147N23O21 |
| Sequence | KQKVTGLDFIPGLHPIL-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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