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Products
Pharmacology
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- Technical support
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U0126
Cat. No. KS-340
Structure:
1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene
Activity:
MAPK inhibitor
U0126 is a potent and selective non-competitive inhibitor of mitogen activated protein kinase (MAPK). U0126 inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively, and has little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. U0126 inhibits both the active and inactive forms of MEK-1/2. U0126 can enhance the self renewal of stem cells and it also helps maintain human pluripotent stem cells in an undifferentiated state. U0126 has an antiproliferative role in cancers, acting through different antitumour mechanisms in different tumours. U0126 is also able to potentiate or antagonise apoptosis, depending on the target cells.
Favata et al (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 273(29) 18623 PMID: 9660836
Duncia et al (1998) MEK inhibitors: the chemistry and biological activity of U0126, its analogs, and cyclization products. Bioorg Med Chem Lett. 8(20) 2839 PMID: 9873633
Pricola (2009) Interleukin-6 maintains bone marrow-derived mesenchymal stem cell stemness by an ERK1/2-dependent mechanism. J Cell Biochem. 2009 108(3) 577 PMID: 19650110
Kinehara et al (2013) Protein kinase C regulates human pluripotent stem cell self-renewal. PLoS One 8(1) e54122 PMID: 23349801
You et al (2022) U0126: Not only a MAPK kinase inhibitor. Front Pharmacol. 13 927083 PMID: 36091807
Related areas
All small molecules >
All kinase modulators >
All cancer research categories >
All stem cell research categories >
Technical Data
| Structure | 1,4-Diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene |
| CAS Number | 109511-58-2 |
| Molecular Weight | 380.49 |
| Formula | C18H16N6S2 |
Solubility and Storage
| Solubility | Soluble in DMSO up to 200 mg/ml |
| Appearance | White solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 99% by HPLC |
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