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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
MDANP
Cat. No. NR-220
Structure:
H-Ser-Lys-Ser-Lys-Lys-Phe-Arg-Arg-Pro-Asp-Ile-Gln-Tyr-Pro-Asp-Ala-Thr-Asp-Glu-Asp-OH
Other Names:
Milk-derived anti-NEC peptide
Activity:
PERK-eIF2ɑ-QRICH1 pathway modulator
MDANP (Milk-derived anti-NEC peptide) is a peptide identified from human milk. Bioactive peptides are an important component of human milk and they exhibit a variety of functions such as anti-infection, immune regulation, and growth promotion. Endoplasmic reticulum (ER) stress plays a critical role in necrotizing enterocolitis (NEC) pathogenesis through the PERK-eIF2ɑ-QRICH1 axis, and in an effort to identify agents in milk which can ameliorate it, MDANP is able to improve intestinal cell apoptosis and has a protective effect in mouse models. That reduction of ER stress by MDANP acts through the PERK-eIF2 α-QRICH1 pathway is shown by MDANP reducing the levels of PERK, p-eIF2, and QRICH1 proteins. MDANP both decreases the severity of NEC in neonatal mouse and ameliorates intestinal injury and reduces apoptosis.
Huo et al (2023) Active polypeptide MDANP protect against necrotizing enterocolitis (NEC) by regulating the PERK-eIF2ɑ-QRICH1 axis. Sci Rep. 13(1) 22912 PMID: 38129421
Related areas
All peptides >
All kinase modulators >
All nuclear receptor modulators >
All immunology research categories >
All regulated cell death research categories >
Technical Data
| Structure | H-Ser-Lys-Ser-Lys-Lys-Phe-Arg-Arg-Pro-Asp-Ile-Gln-Tyr-Pro-Asp-Ala-Thr-Asp-Glu-Asp-OH |
| Molecular Weight | 2395.18 |
| Formula | C103H162N30O36 |
| Sequence | SKSKKFRRPDIQYPDATDED |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in saline |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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