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Torin 1
Cat. No. KS-270
Structure:
1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Other Names:
mTOR Inhibitor XI
Activity:
mTOR inhibitor
Torin 1 is a potent and selective ATP-competitive mammalian target of rapamycin (mTOR) inhibitor, with IC50 values of 2 and 10 nM for mTORC1 and mTORC2 respectively and 200-fold selectivity over ATM, DNA-PK, and hVps34: additionally it does not significantly inhibit a panel of 353 serine/threonine, tyrosine, and lipid kinases at 10 μM. Torin 1 impairs cell growth and proliferation by suppression of the rapamycin-resistant functions of mTORC1 and has also been shown to cause cell cycle arrest via a rapamycin-resistant mechanism independent of mTORC2. Torin 1 induces autophagy, and in animal models, also has anti-inflammatory, anti-cancer, and anti-aging properties and shows activity against neuropathic pain.
Liu et al (2010) Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem. 53(19) 7146 PMID: 20860370
Hong et al (2013) Autophagy sensitivity of neuroendocrine lung tumor cells. Int J Oncol. 43(6) 2031 PMID: 24126619
Jhanwar-Uniyal et al (2022) Disentangling the signaling pathways of mTOR complexes, mTORC1 and mTORC2, as a therapeutic target in glioblastoma. Adv Biol Regul. 83 100854 PMID: 34996736
Related areas
All small molecules >
All kinase modulators >
All cancer research categories >
All regulated cell death research categories >
All pain research categories >
Technical Data
| Structure | 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one |
| CAS Number | 1222998-36-8 |
| Molecular Weight | 607.62 |
| Formula | C35H28F3N5O2 |
Solubility and Storage
| Solubility | Soluble to 1 mM in DMSO with gentle warming |
| Appearance | White solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 98% by HPLC. NMR conforms |
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