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Products
Pharmacology
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- Technical support
- Resources
A20FMDV2
Cat. No. IG-010
Structure:
H-Asn-Ala-Val-Pro-Asn-Leu-Arg-Gly-Asp-Leu-Gln-Val-Leu-Ala-Gln-Lys-Val-Ala-Arg-Thr-NH2
Activity:
Selective alpha-v beta-6 (αvβ6) integrin antagonist
A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding integrin, inhibiting alphavbeta6-ligand binding with a IC50 of 3 nmol/L, an activity 1,000-fold more selective for alphavbeta6 than for other RGD-directed integrins (alphavbeta3, alphavbeta5, and alpha5beta1).
Hausner et al (2007) Use of a Peptide Derived from Foot-and-Mouth Disease Virus for the Noninvasive Imaging of Human Cancer: Generation and Evaluation of 4-[18F]Fluorobenzoyl A20FMDV2 for In vivo Imaging of Integrin αvβ6 Expression with Positron Emission Tomography. Cancer Res. 67(16) 7833 PMID: 17699789
Slack et al (2016) Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2. Pharmacology 97(3-4) 114 PMID: 26734728
Related areas
All peptides >
All antivirals >
All integrin receptor modulators >
Technical Data
| Structure | H-Asn-Ala-Val-Pro-Asn-Leu-Arg-Gly-Asp-Leu-Gln-Val-Leu-Ala-Gln-Lys-Val-Ala-Arg-Thr-NH2 |
| Molecular Weight | 2162.5 |
| Formula | C93H164N32O27 |
| Sequence | NAVPNLRGDLQVLAQKVART-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | We recommend storage desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Certificate of Analysis | IG-010-1MG A20FMDV2_621f93fc8865d.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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