The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
T2857W
Cat. No. PP-450
Structure:
H-Pro-Ser-Asp-Ile-Met-Asp-Phe-Val-Leu-Lys-Asn-Trp-OH
Other Names:
T2857W mutant of the MLL TAD peptide
Activity:
KIX–MLL interaction inhibitor
T2857W is a kinase-inducible domain interacting (KIX) inhibitor designed from a peptide fragment corresponding to the transactivation domain (TAD) of the transcriptional activator, mixed-lineage leukemia protein (MLL). The KIX domain is an integral part of the general transcriptional coactivator CREB binding protein, and has been associated with leukemia, cancer, and various viral diseases. KIX is a small globular domain with two binding sites, the c-Myb site and MLL site, which bind the transcriptional activators c-Myb and MLL, respectively. T2857W is the mutant of the MLL TAD peptide identified as having the highest binding affinity for KIX from a series, with a twofold higher affinity for KIX than the wild-type MLL, and is effective in inhibiting the KIX–MLL interaction. T2857W also shows some selectivity for the MLL–KIX interaction over the c-Myb–KIX interaction.
Sato et al (2023) Rational peptide design for inhibition of the KIX-MLL interaction. Sci Rep. 13(1) 6330 PMID: 37072438
Related areas
All peptides >
All protein-protein interaction modulators >
All cancer research categories >
All antivirals >
Technical Data
| Structure | H-Pro-Ser-Asp-Ile-Met-Asp-Phe-Val-Leu-Lys-Asn-Trp-OH |
| Molecular Weight | 1463.71 |
| Formula | C68H101N15O19S |
| Sequence | PSDIMDFVLKNW |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2025 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio