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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Octpep-1
Cat. No. KS-240
Structure:
H-Asp-Pro-Pro-Ser-Asp-Asp-Glu-Phe-Val-Ser-Leu-Met-OH
Activity:
Targets PI3K/AKT/mTOR signaling
Octpep-1 is a peptide derived from the octopus kaurna, or the southern sand octopus, a species native to the seas around the Great Australian Bight and Tasmania. Octpep-1 disrupts PI3K/AKT/mTOR pathway signalling and selectively reduces the proliferative capacity of human melanoma BRAFV600E mutated cells, with minimal effects on fibroblasts. Octpep-1 has weak agonist activity at tachykinin NK1 receptors but its antiproliferative activity is independent of NK1R expression. Octpep-1 acts synergistically in combination with the mTORC1 inhibitor rapamycin or the ERK1/2 inhibitor LY3214996 to enhance its antiproliferative effects and augment cytotoxicity. Octpep-1 reduces the progression of tumours in vivo, being effective in xenograft mouse melanoma and zebrafish models.
Moral-Sanz et al (2021) ERK and mTORC1 Inhibitors Enhance the Anti-Cancer Capacity of the Octpep-1 Venom-Derived Peptide in Melanoma BRAF(V600E) Mutations. Toxins (Basel) 13(2) 146 PMID: 33672955
Moral-Sanz (2022) The structural conformation of the tachykinin domain drives the anti-tumoural activity of an octopus peptide in melanoma BRAFV600E. Br J Pharmacol. 179(20) 4878 PMID: 35818835
IUPHAR-BPS Guide to pharmacology - Octpep-1
Related areas
All peptides >
All kinase modulators >
All cancer research categories >
Technical Data
| Structure | H-Asp-Pro-Pro-Ser-Asp-Asp-Glu-Phe-Val-Ser-Leu-Met-OH |
| Molecular Weight | 1350.56 |
| Formula | C58H86N12O23S |
| Sequence | DPPSDDEFVSLM |
| Modifications | None |
Solubility and Storage
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >98% by hplc |
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