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Products
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- Resources
RMR
Cat. No. PP-440
Structure:
H-Arg-Met-Arg-Val-Thr-Pro-Ser-Thr-Pro-Ser-Pro-Arg-OH
Other Names:
RMR peptide
Activity:
Disrupts
PAK1–RUNX3 interaction
RMR is a peptide derived from the protein sequence flanking the threonine 209 phosphorylation site of the Runt-related transcription factor 3 (RUNX3) protein, chosen based on docking efficiency with the active site of P21 Activated Kinase 1 (PAK1), and ability to displace PAK1–RUNX3 interaction in models. PAK1 is an oncogenic serine/threonine kinase which modulates several signaling pathways involved in cancer, and phosphorylation of RUNX3 at T209 by PAK1 switches the function of RUNX3 from tumour suppressor to oncogene. RMR peptide is stable in vitro and in vivo, non toxic to normal cells, and inhibits threonine 209 phosphorylation in RUNX3 by PAK1. In cell culture models RMR peptide reduces proliferation of human oral squamous cell carcinoma samples, and in vivo causes 33% tumour regression in tumour xenograft models.
Kanumuri et al (2020) Small peptide inhibitor from the sequence of RUNX3 disrupts PAK1-RUNX3 interaction and abrogates its phosphorylation-dependent oncogenic function. Oncogene 40(34) 5327 PMID: 34253860
Related areas
All peptides >
All kinase modulators >
All protein-protein interaction modulators >
All nuclear receptor modulators >
All cancer research categories >
Technical Data
| Structure | H-Arg-Met-Arg-Val-Thr-Pro-Ser-Thr-Pro-Ser-Pro-Arg-OH |
| Molecular Weight | 1383.74 |
| Formula | C57H101N21O17S |
| Sequence | RMRVTPSTPSPR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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