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AtPep1
Cat. No. PL-030
Structure:
H-Ala-Thr-Lys-Val-Lys-Ala-Lys-Gln-Arg-Gly-Lys-Glu-Lys-Val-Ser-Ser-Gly-Arg-Pro-Gly-Gln-His-Asn-OH
Other Names:
Elicitor peptide 1, Pep1
Activity:
Plant elicitor peptide
AtPep1 is an endogenous peptide elicitor from Arabidopsis leaves that signals the activation of components of the innate immune response against pathogens. Atpep1 derives from the carboxyl terminal of the precursor propeptide PROPEP1, and on microbe-associated molecular pattern (MAMP) perception or cell damage, vacuolar membrane-resident PROPEP1 is processed by type II metacaspases to release AtPep1 which binds to the leucine-rich repeat receptor kinase (LLR-RK) PEPR1. AtPep1 binding to PEPR1 leads to heterodimerization with the shared receptor kinase Brassinosteroid-Insensitive 1-Associated Receptor Kinase 1 (BAK1) and consequent activation of the receptor complex, resulting in immune responses similar to those induced by pathogens.
Yamaguchi et al (2006) The cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells. Proc Natl Acad Sci U S A 103(26) 10104 PMID: 16785433
Tang et al (2015) Structural basis for recognition of an endogenous peptide by the plant receptor kinase PEPR1. Cell Res. 25(1) 110 PMID: 25475059
Zhang et al (2022) Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling in Arabidopsis. Plant Signal Behav. 17(1) 2034270 PMID: 35164659
Eastman et al (2024) A type II secreted subtilase from commensal rhizobacteria cleaves immune elicitor peptides and suppresses flg22-induced immune activation. Cell Rep. 43(12) 115063 PMID: 39673709
Related areas
All peptides >
All kinase modulators >
All plant science products >
Technical Data
| Structure | H-Ala-Thr-Lys-Val-Lys-Ala-Lys-Gln-Arg-Gly-Lys-Glu-Lys-Val-Ser-Ser-Gly-Arg-Pro-Gly-Gln-His-Asn-OH |
| CAS Number | 902781-11-7 |
| Molecular Weight | 2490.39 |
| Formula | C104H183N39O32 |
| Sequence | ATKVKAKQRGKEKVSSGRPGQHN |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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