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Pharmacology
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- Technical support
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MOTS-c
Cat. No. KS-210
Structure:
H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Other Names:
Mitochondria-derived peptide MOTS-c, Mitochondrial open reading frame of the 12S rRNA-c
Activity:
AMPK activator
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame (sORF) within the mitochondrial 12S rRNA. MOTS-c, which is a contraction of mitochondrial open reading frame of the 12S rRNA-c, regulates insulin sensitivity and metabolic homeostasis with its primary target organ being skeletal muscle. The cellular action of MOTS-c is to inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to activation of AMP-activated protein kinase (AMPK), a central regulator of energy homeostasis. In mouse models, MOTS-c treatment prevents age dependent and high fat diet-induced insulin resistance, as well as diet induced obesity.
Lee et al (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 21(3) 443 PMID: 25738459
Wei et al (2020) Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway. Cardiorenal Med. 10(1) 42 PMID: 31694019
Reynolds et al (2021) MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 12(1) 470 PMID: 33473109
Kong et al (2025) Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes. Exp Mol Med https://doi.org/10.1038/s12276-025-01521-1
Related areas
All peptides >
All kinase modulators >
All diabetes research categories >All metabolism research categories >
Technical Data
| Structure | H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH |
| CAS Number | 627580-64-6 |
| Molecular Weight | 2174.62 |
| Formula | C101H152N28O22S2 |
| Sequence | MRWQEMGYIFYPRKLR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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