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Products
Pharmacology
Type
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- Custom services
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- Technical support
- Resources
MBP (4-14)
Cat. No. KS-140
Structure:
H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH
Other Names:
Myelin Basic Protein Fragment (4-14)
Activity:
Highly selective substrate for protein kinase C (PKC)
MBP (4-14), also known as Myelin Basic Protein Fragment (4-14), is a synthetic peptide having the sequence surrounding Ser(8) of myelin basic protein, and is a highly selective substrate for protein kinase C (PKC). MBP (4-14) is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca2+/calmodulin-dependent protein kinase II, or phosphorylase kinase. MBP (4-14) is routinely used for the assay of protein kinase C.
Yasuda et al (1990) A synthetic peptide substrate for selective assay of protein kinase C. Biochem. Biophys. Res. Commun. 166(3) 1220 PMID: 1689574
Verbeek et al (2005) Protein kinase C gamma mutations in spinocerebellar ataxia 14 increase kinase activity and alter membrane targeting. Brain 128(2) 436 PMID: 15618281
Tandon et al (2013) New Pyrazolopyrimidine Inhibitors of Protein Kinase D as Potent Anticancer Agents for Prostate Cancer Cells. PLoS ONE 8(9) e75601 PMID: 24086585
Related data
Technical Data
| Structure | H-Gln-Lys-Arg-Pro-Ser-Gln-Arg-Ser-Lys-Tyr-Leu-OH |
| CAS Number | 126768-94-3 |
| Molecular Weight | 1390.6 |
| Formula | C60H103N21O17 |
| Sequence | QKRPSQRSKYL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | MBP (4-14) MSDS_602bf7c3a45bb.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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