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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
F9170
Cat. No. AV-010
Structure:
H-Gly-Trp-Glu-Ala-Leu-Lys-Tyr-Leu-Trp-Asn-Leu-Leu-Gln-Tyr-Trp-OH
Activity:
Inactivates HIV-1 virions
F9170 is a peptide identified from the cytoplasmic region of the HIV-1 envelope glycoprotein
(Env, gp120-gp41) which is able to inactivate HIV-1 virions and induce necrosis of HIV-1 infected cells. F9170
can enter the brain and lymph nodes and specifically targets the conserved cytoplasmic tail of HIV-1 Env to disrupt the integrity of the viral
membrane. F9170 short term administration can control viral loads to below the limit of detection in
chronically SHIV infected macaques.
Wang et al (2020) An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells. Sci Transl Med. 12(546):eaaz2254 PMID: 32493792
Related data
Technical Data
| Structure | H-Gly-Trp-Glu-Ala-Leu-Lys-Tyr-Leu-Trp-Asn-Leu-Leu-Gln-Tyr-Trp-OH |
| Molecular Weight | 1983.30 |
| Formula | C100H135N21O22 |
| Sequence | GWEALKYLWNLLQYW |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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