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Parathyroid hormone (1-34) (rat)
Cat. No. PH-040
Structure:
H-Ala-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ala-Ser-Val-Glu-Arg-Met-Gln-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
Other Names:
pTH (1-34) (rat)
Activity:
Parathyroid hormone (PTH) receptor agonist
Parathyroid hormone (1-34) (rat) is a parathyroid hormone receptor agonist, which can increase serum parathyroid hormone levels and bone mass in rats. Parathyroid hormone (1-34) (rat) treatment significantly improved weight bearing and treadmill endurance, preserved GAG and collagen type II, and reduced the OARSI score and terminal differentiation markers in rat models of osteoarthritis. Parathyroid hormone (1–34) (rat) alleviates disease progression in a papain induced osteoarthritis in vivo rat model.
Yu and Chandrasekhar (1997) Parathyroid hormone (PTH 1-34) regulation of rat osteocalcin gene transcription. Endocrinology 138(8) 3085 PMID: 9231754
Chang et al (2009) Parathyroid hormone 1-34 inhibits terminal differentiation of human articular chondrocytes and osteoarthritis progression in rats. Arthritis Rheum. 60(10) 3049 PMID: 19790062
Chen et al (2018) Parathyroid hormone-(1-34) ameliorated knee osteoarthritis in rats via autophagy. J Appl Physiol (1985) 124(5) 1177 PMID: 29357491
Related areas
All peptides >
All parathyroid hormone receptor modulators >
All endocrinology research categories >
All immunology research categories >
Technical Data
| Structure | H-Ala-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ala-Ser-Val-Glu-Arg-Met-Gln-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH |
| CAS Number | 98614-76-7 |
| Molecular Weight | 4057.74 |
| Formula | C180H291N55O48S2 |
| Sequence | AVSEIQLMHNLGKHLASVERMQWLRKKLQDVHNF |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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