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- Technical support
- Resources
Crosstide, biotinylated
Cat. No. KS-071
Structure:
Biotin-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH
Activity:
Akt/PKB (protein kinase B) substrate
Crosstide is a synthetic peptide derived from glycogen synthase kinase-3β (GSK-3). Crosstide functions as substrate for Akt/PKB (protein kinase B) and is also recognized by MAPKAP kinase-1 and p70S6K, Crosstide also displays similar selectivity towards PKBα, PKBβ and PKBγ isoforms. The fluorescent and biotinylated version of crosstide demonstrate similar enzymic activity. The N-terminal biotin tag allows subsequent protein detection and purification.
Dai (2002) Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3β) at serine-9 through direct interaction Biochem. Biophys. Res. Comm. 293 (4) 1191 PMID: 12054501
Baer et al (2005) Activation of a GST-tagged AKT2/PKBbeta. Biochim. Biophys. Acta 1725(3) 340 PMID: 15890450
Xu et al (2005) WNK1 Activates SGK1 by a Phosphatidylinositol 3-Kinase-dependent and Non-catalytic Mechanism. J. Biol. Chem. 280 34218 PMID: 16081417
Related areas
All biotin labelled peptides >
All kinase modulators >
All substrate peptides >
Technical Data
| Structure | Biotin-Gly-Arg-Pro-Arg-Thr-Ser-Ser-Phe-Ala-Glu-Gly-OH |
| Molecular Weight | 1390.4 |
| Formula | C58H91N19O19S |
| Sequence | Biotin-GRPRTSSFAEG |
| Modifications | Biotin at N terminal |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Crosstide, biotinylated MSDS_602bad64677f7.pdf |
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Recent citations
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