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Kisspeptin 234
Cat. No. KR-010
Structure:
Ac-(D)Ala-Asn-Trp-Asn-Gly-Phe-Gly-(D)Trp-Arg-Phe-NH2
Other Names:
Peptide 234, p234, K234
Activity:
Kisspeptin receptor antagonist
Kisspeptin 234 is an analogue of kisspeptin 10 which acts as a kisspeptin receptor antagonist. Of a series, kisspeptin 234 most potently inhibited kisspeptin 10 stimulation of inositol phosphate release in Chinese hamster ovarian cells stably expressing the human GPR54 with an IC50 of 7 nM. Intracerebroventricular administration of kisspeptin 234 causes delayed vaginal opening in rats (an indicator of puberty) and prevents an increase in circulating luteinising hormone concentration when co-administrated with kisspeptin 10.
Roseweir et al (2009) Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadototrophin regulation. J.Neurosci. 29 3920 PMID: 19321788
Millar et al (2010) Kisspeptin antagonists: unraveling the role of kisspeptin in reproductive physiology. Brain Res. 1364 81 PMID: 20858467
lbers-Wolthers et al (2017) In vitro and in vivo effects of kisspeptin antagonists p234, p271, p354, and p356 on GPR54 activation. PLoS One 2(6) e0179156 PMID: 28650956
Dinh et al (2023) The kisspeptin-1 receptor antagonist peptide-234 aggravates uremic cardiomyopathy in a rat model. Sci Rep. 13(1) 14046 PMID: 37640761
Related areas
All peptides >
All kisspeptin receptor modulators >
All endocrinology research categories >
All cancer research categories >
Technical Data
| Structure | Ac-(D)Ala-Asn-Trp-Asn-Gly-Phe-Gly-(D)Trp-Arg-Phe-NH2 |
| CAS Number | 1145998-81-7 |
| Molecular Weight | 1295.42 |
| Formula | C63H78N18O13 |
| Sequence | Ac-aNWNGFGwRF-NH2 |
| Modifications | N-terminal acetyl, C-terminal amide; Ala-1 is D-Ala and Trp-8 is D-Trp |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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