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[Des-octanoyl]-Ghrelin (human)
Cat. No. GR-010
Structure:
H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
Other Names:
Des-acyl ghrelin, Unacylated ghrelin, UAG
Activity:
Non acylated form of ghrelin
[Des-octanoyl]-Ghrelin (human) is the more stable, non-acylated and major circulating isoform of ghrelin (human), with a a half-life of 35 min in plasma compared with 10 minutes for acylated ghrelin. Unlike ghrelin, [des-octanoyl]-ghrelin (human) does not bind to the ghrelin receptor (GHS-R1a), or induce growth hormone release. [Des-octanoyl]-ghrelin (human) exerts negative inotropic effects in papillary muscle and displays cardioprotective activity, inhibits cell proliferation in breast and prostate cancer cell lines and promotes adipogenesis in vivo.
Baldanzi et al (2002) Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J.Cell Biol. 159 1029 PMID: 12486113
Gauna et al (2005) Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes. J Clin Endocrinol Metab. 90(2) 1055 PMID: 15536157
Petrescu et al (2020) Ghrelin reverses ductular reaction and hepatic fibrosis in a rodent model of cholestasis. Sci Rep 10 16024 https://doi.org/10.1038/s41598-020-72681-5
Iwakura et al (2023) Desacyl-ghrelin, not just an inactive form of ghrelin? A review of current knowledge on the biological actions of desacyl-ghrelin. Peptides 167 171050 PMID: 37392995.
Related areas
All peptides >
All ghrelin receptor modulators >
All endocrinology research categories >
All cancer research categories >
Technical Data
| Structure | H-Gly-Ser-Ser-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH |
| CAS Number | 313951-59-6 |
| Molecular Weight | 3244.51 |
| Formula | C141H235N47O41 |
| Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQPR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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