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7-Transmembrane receptors
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Ghrelin receptors
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Ghrelin (human)
Ghrelin (human)
Cat. No. GH-190
Structure:
H-Gly-Ser-Ser(n-octanoyl)Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
Activity:
Endogenous agonist peptide for the ghrelin receptor
Ghrelin (human) is the endogenous agonist peptide for the ghrelin receptor (growth hormone secretagogue type 1A receptor or GHS-R). Ghrelin (human) is produced mainly by the stomach, and is linked to inducing appetite and feeding behaviour, with circulating ghrelin levels being highest before a meal and the lowest after. Injections of ghrelin (human) in both humans and rats have been shown to increase food intake in a dose-dependent manner and also to increase motivation to seek out food.
Inui (2001) Ghrelin: an orexigenic and somatotrophic signal from the stomach. Nat.Rev.Neurosci. 2 551 PMID: 11483998
Kojima et al (1999) Ghrelin is growth-hormone-releasing acylated peptide from stomach. Nature 402 656 PMID: 10604470
Tolle et al (2001) In vivo and in vitro effects of ghrelin/motilin-related peptide on GH secretion in the rat. Neuroendocrinology 73 54 PMID: 11174017
Related areas
All peptides >
All ghrelin receptor modulators >
All endocrinology research categories >
All appetite regulation research categories >
Technical Data
| Structure | H-Gly-Ser-Ser(n-octanoyl)Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH |
| CAS Number | 258279-04-8 |
| Molecular Weight | 3370.9 |
| Formula | C149H249N47O42 |
| Sequence | GSSFLSPEHQRVQQRKESKKPPAKLQPR |
| Modifications | Ser-3 is n-octanoyl substituted |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Ghrelin (human) MSDS_602c062eee517.pdf |
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