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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
γ-2
Cat. No. PT-120
Structure:
Ntri-NLys-Ntma
Other Names:
gamma2
Activity:
Lipopeptoid with antifungal activity
γ-2 is a trimeric lipopeptoid with antifungal activity against Cryptococcus neoformans and minimal mammalian cell toxicity. γ-2 is an optimized derivation of AEC5 and has improved potency towards C. neoformans and decreased toxicity towards NIH/3T3 mouse fibroblasts, with a selectivity ratio improved from 8 for AEC5 to 21 for γ-2.
Middleton et al (2018) Improved Potency and Reduced Toxicity of the Antifungal Peptoid AEC5 Through Submonomer Modification. Bioorg. Med. Chem. Lett. 28(22) 3514 PMID: 30297282
Related areas
Licencing Information
Sold under license from Middle Tennessee State University
Technical Data
| Structure | Ntri-NLys-Ntma |
| Molecular Weight | 537.8 |
| Formula | C28H51N5O3S |
| Sequence | Ntri-NLys-Ntma |
| Modifications | For more information about peptoids and their nomenclature please refer to the resources section |
Solubility and Storage
| Solubility | >50 mg per ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 95.5% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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