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AEC5

Cat. No. PT-109

Structure:

Ntri-NLys-Nfur

Activity:

Lipopeptoid with antifungal activity against Cryptococcus neoformans
Price Qty
1 mg    $ 205.00

AEC5 is a trimeric lipopeptoid with potent antifungal activity against Cryptococcus neoformans and Cryptococcus gattii and modest efficacy against other microbial pathogens.  AEC5 rapidly reduces fungal burden in infected macrophages against C. neoformans, with nearly 50% reduction in fungal growth after 30 minutes and complete elimination of viable fungi within 3 hours.  In mouse models AEC5 has an in vivo half-life of >20 hours and no observable toxicity following 28 days of daily injections.

Corson (2016) Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. ACS Med Chem Lett. 7(12) 1139 PMID: 27994753

Spicer et al (2019) Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5. Biopolymers 110(6) e23276 PMID: 30938841


Related areas

All peptoids >
All antifungals >


Licencing Information

Sold under license from Middle Tennessee State University

Technical Data

Structure Ntri-NLys-Nfur
Molecular Weight 521.7
Formula C28H51N5O4
Sequence Ntri-NLys-Nfur
Modifications For more information about peptoids and their nomenclature please refer to the resources section

Solubility and Storage

Solubility >50 mg per ml in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity 96.2% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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