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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
AEC5
Cat. No. PT-109
Structure:
Activity:
AEC5 is a trimeric lipopeptoid with potent antifungal activity against Cryptococcus neoformans and Cryptococcus gattii and modest efficacy against other microbial pathogens. AEC5 rapidly reduces fungal burden in infected macrophages against C. neoformans, with nearly 50% reduction in fungal growth after 30 minutes and complete elimination of viable fungi within 3 hours. In mouse models AEC5 has an in vivo half-life of >20 hours and no observable toxicity following 28 days of daily injections.
Corson (2016) Discovery and Characterization of a Peptoid with Antifungal Activity against Cryptococcus neoformans. ACS Med Chem Lett. 7(12) 1139 PMID: 27994753
Spicer et al (2019) Toward a clinical antifungal peptoid: Investigations into the therapeutic potential of AEC5. Biopolymers 110(6) e23276 PMID: 30938841
Related areas
Licencing Information
Technical Data
Structure | Ntri-NLys-Nfur |
Molecular Weight | 521.7 |
Formula | C28H51N5O4 |
Sequence | Ntri-NLys-Nfur |
Modifications | For more information about peptoids and their nomenclature please refer to the resources section |
Solubility and Storage
Solubility | >50 mg per ml in water |
Appearance | Freeze dried solid |
Storage | Store dry, frozen and in the dark |
Batch Specific Data
Purity | 96.2% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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