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Autocamtide-2-related inhibitory peptide
Cat. No. KS-190
Structure:
H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH
Other Names:
AIP
Activity:
CaM kinase II inhibitor
Autocamtide-2-related inhibitory peptide is a selective and potent calmodulin-dependent protein kinase II (CaM kinase II) inhibitor with an IC50 of 40 nM. Autocamtide-2-related inhibitory peptide is selective over PKC, PKA and CaM kinase IV, with IC50's greater than 10 μM for each. Autocamtide 2–related inhibitory peptide reverses CaMKII mediated effects in cardiac channels but does not alter INa gating.
Ishida et al (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem.Biophys.Res.Commun. 212 806 PMID: 7626114
Wagner et al (2006) Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. 116(12) 3127 https://doi.org/10.1172/JCI26620.
Ikeda et al (2019) Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway. Sci Rep 9 9850 https://doi.org/10.1038/s41598-019-46367-6
Feng et al (2023) The CaMKII Inhibitory Peptide AIP Alleviates Renal Fibrosis Through the TGF-β/Smad and RAF/ERK Pathways. J Pharmacol Exp Ther. 386(3) 310 PMID: 37419684
Related areas
All peptides >
All kinase modulators >
All cardiovascular research categories >
Technical Data
| Structure | H-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH |
| CAS Number | 167114-91-2 |
| Molecular Weight | 1497.76 |
| Formula | C64H116N22O19 |
| Sequence | KKALRRQEAVDAL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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