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Products
Pharmacology
Type
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- Custom services
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- Technical support
- Resources
Neurokinin B (human, porcine)
Cat. No. TK-010
Structure:
H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2
Other Names:
NKB
Activity:
NK3 selective endogenous tachykinin agonist
Neurokinin B (human, porcine) is a tachykinin agonist peptide that shows preference for the NK3 receptor, with an EC50 of 1 nM. Neurokinin B (human, porcine) is an important endogenous neuropeptide and contributes to luteinizing hormone secretion, the estrous cycle, energy balance, dynamics of fetus in placenta, and contraction in uterine muscles of rat. Loss of function mutations in the genes encoding either neurokinin B or its receptor, NK3 result in hypogonadotropic hypogonadism, implicating NKB and NK3 as essential elements of the human reproductive axis.
Laufer et al (1985) Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc.Natl.Acad.Sci.U.S.A. 82 7444 PMID: 2414777
Rance et al (2010) Neurokinin B and the hypothalamic regulation of reproduction. Brain Res. 1364 116 PMID: 20800582
Asmat et al (2020) Exogenous Neurokinin B Administration May Have a Strong Effect on Negative Feedback Loop of Hypothalamic Pituitary Thyroid Axis. Int. J. Peptide Res. Ther. 26 1259 https://doi.org/10.1007/s10989-019-09925-0
Related Areas
All peptides >
All tachykinin receptor modulators >
All endocrinology research categories >
All neuroscience research categories >
Technical Data
| Structure | H-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2 |
| CAS Number | 86933-75-7 |
| Molecular Weight | 1210.43 |
| Formula | C55H79N13O14S2 |
| Sequence | DMHDFFVGLM-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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