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Pharmacology
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ZIP
Cat. No. KS-170
Structure:
Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
Other Names:
z-Pseudosubstrate inhibitory peptide, Zeta inhibitory peptide, PKCζ (113-125), myristoylated
Activity:
Protein kinase Mζ inhibitor
ZIP, or Zeta inhibitory peptide, is a cell permeable pseudo-substrate inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ induced synaptic potentiation in hippocampal slices in vitro and is widely used to investigate memory in a variety of learning tasks, including spatial sensitization, pain sensitization, fear-associated memories, conditioned taste aversion and development of locomotor sensitization in rodents. However, LTP and LTM are unaffected in both constitutive and conditional PKMζ knock-out mice, yet both are still impaired by ZIP application, suggesting another mechanism of action which may involve ionotropic glutamate AMPA receptors (AMPARs).
Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979 PMID: 15728837
LeBlancq et al (2016) ZIP It: Neural Silencing Is an Additional Effect of the PKM-Zeta Inhibitor Zeta-Inhibitory Peptide. J. Neuroscience 36 (23) 6193 DOI: 10.1523/JNEUROSCI.4563-14.2016
Bingor et al (2020) Zeta Inhibitory Peptide attenuates learning and memory by inducing NO-mediated downregulation of AMPA receptors. Nat Commun 11 3688 https://doi.org/10.1038/s41467-020-17484-y
Stokes et al (2025) Cationic peptides cause memory loss through endophilin-mediated endocytosis. Nature. https://doi.org/10.1038/s41586-024-08413-w
Related areas
All peptides >
All kinase modulators >
All neuroscience categories >
Technical Data
| Structure | Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH |
| CAS Number | 863987-12-6 |
| Molecular Weight | 1928.4 |
| Formula | C90H154N30O17 |
| Sequence | Myr-SIYRRGARRWRKL |
| Modifications | N terminal myristoyl |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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