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Products
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- Technical support
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alpha-MSH
Cat. No. MC-010
Structure:
AcSer-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Other Names:
a-Melanotropin, a-N-acetyl-ACTH(1-13)-NH2, alpha-melanocyte-stimulating hormone
Activity:
Endogenous melanocortin receptor agonist
alpha-MSH is an endogenous melanocortin receptor agonist with Ki values of 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively. alpha-MSH is primarily a pigmentary hormone of the vertebrates and reduces the concentration of proinflammatory mediators through the induction of cyclic adenosine monophosphate (cAMP), controlling inflammation in the brain and peripheral organs. alpha-MSH also possesses antimicrobial properties.
D'Agostino and Diano (2010) Alpha-melanocyte stimulating hormone: production and degradation. J Mol Med (Berl). 88(12) 1195 PMID: 20617297
Singh and Mukhopadhyay (2014) Alpha-Melanocyte Stimulating Hormone: An Emerging Anti-Inflammatory Antimicrobial Peptide BioMed Research International Article ID 874610 PMID: 25140322
Kravchychyn et al (2018) The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents. Ann Nutr Metab. 72 279 PMID: 29649791
Related areas
All peptides >
All melanocortin receptor modulators >
All endocrinology research categories >
All immunology research categories >
All antimicrobial agents >
Technical Data
| Structure | AcSer-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| CAS Number | 581-05-5 |
| Molecular Weight | 1664.88 |
| Formula | C77H109N21O19S |
| Sequence | AcSYSMEHFRWGKPV-NH2 |
| Modifications | N terminal acetyl, C terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.60 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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