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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
Glucagon (1-29)
Cat. No. GL-010
Structure:
H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
Other Names:
Glucagon (1-29) (human, rat, porcine)
Activity:
Endogenous glucagon receptor agonist
Glucagon (1-29) is a 29 amino acid containing peptide hormone processed from proglucagon and released from pancreatic islet α-cells. Glucagon (1-29) acts as a counterregulatory hormone for insulin, and plays a critical role in maintaining glucose homeostasis in animals and humans. Glucagon (1-29) and glucagon receptors are targets for the therapeutic treatment of diabetes.
Thomsen et al (1972) The amino acid sequence of human glucagon. FEBS Lett. 21(3) 315 PMID: 11946536
Pospisilik et al (2001) Metabolism of glucagon by dipeptidyl peptidase IV (CD26), Regulatory Peptides 96(3) 133 PMID: 11111019
Holst et al (2011), Regulation of glucagon secretion by incretins. Diabetes, Obesity and Metabolism 13 89 PMID: 21824261
Related areas
All peptides >
All glucagon and related receptor modulators >
All endocrinology research categories >
All diabetes research categories >
Technical Data
| Structure | H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH |
| CAS Number | 16941-32-5 |
| Molecular Weight | 3482.79 |
| Formula | C153H225N43O49S |
| Sequence | HSQGTFTSDYSKYLDSRRAQDFVQWLMNT |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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