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Products
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N4-Hydroxycytidine
Cat. No. CV-030
Structure:
1-[2R,3R,4S,5R-3,4-Dihydroxy-5-hydroxymethyloxolan-2-yl]-4-hydroxyaminopyrimidin- 2-one
Activity:
Broad spectrum antiviral
N4-Hydroxycytidine is a broad spectrum antiviral with activity against a range of viruses including hepatitis C, norovirus, Ebola virus, influenza, respiratory syncytial viruses and coronaviruses. N4-hydroxycytidine has been shown to inhibit SARS-CoV-2 as well as other human and bat coronaviruses in mice and human airway epithelial cells. N4-hydroxycytidine is the active molecule in the antiviral pro-drug clinical candidate EIDD 2801, which is also being investigated for its broad spectrum activity against the coronavirus family of viruses. EIDD 2801 exerts its antiviral action through introduction of copying errors during viral RNA replication and is active against SARS, MERS and SARS-CoV-2.
Janion and Glickman (1980) N4-hydroxycytidine: a mutagen specific for AT to GC transitions. Mutat. Res. 72(1) 43 PMID: 6160396
Pyrc et al (2006) Inhibition of Human Coronavirus NL63 Infection at Early Stages of the Replication Cycle. Antimicrob. Agents Chemother. 50(6) 2000 PMID: 16723558
Toots et al (2019) Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia. Sci. Trans. Med. 11(515) eaax5866 PMID: 31645453
Related areas
Technical Data
| Structure | 1-[2R,3R,4S,5R-3,4-Dihydroxy-5-hydroxymethyloxolan-2-yl]-4-hydroxyaminopyrimidin- 2-one |
| CAS Number | 3258-02-4 |
| Molecular Weight | 259.2 |
| Formula | C9H13N3O6 |
| Sequence | 1-[2R,3R,4S,5R-3,4-Dihydroxy-5-hydroxymethyloxolan-2-yl]-4-hydroxyaminopyrimidin- 2-one |
Solubility and Storage
| Solubility | Soluble in water to 15mg/ml or DMSO to 25mg/ml |
| Appearance | White powder |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >98% by hplc; NMR conforms |
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Recent citations
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