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Products
Pharmacology
Type
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- Technical support
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Neuropeptide Y (human, rat)
Cat. No. GH-060
Structure:
H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
Activity:
Endogenous neuropeptide Y receptor agonist
Neuropeptide Y (human, rat) is a widely distributed endogenous neuropeptide which mediates its physiological effects through at least four receptors, Y1, Y2, Y4, and Y5. Neuropeptide Y (human, rat) is one of the most abundant peptides in the central nervous system and is highly conserved throughout evolution. Neuropeptide Y (human, rat) is involved in a range of biochemical processes including appetite control, sexual behaviour and blood pressure regulation.
Michel et al (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol.Rev. 50 143 PMID: 9549761
Morales-Medina et al (2010) A possible role of neuropeptide Y in depression and stress. Brain Res. 1314 194 PMID: 19782662
Holzer et al (2012) Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides 2012 46(6) 261 PMID: 22979996
Related areas
All peptides >
All neuropeptide Y receptor modulators >
All neuroscience research categories >
All appetite regulation research categories >
All cardiovascular research categories >
Technical Data
| Structure | H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2 |
| CAS Number | 90880-35-6 |
| Molecular Weight | 4271.7 |
| Formula | C189H285N55O57S |
| Sequence | YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store in the dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
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