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Products
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- Resources
PKI (14-22) amide, myristoylated
Cat. No. KS-110
Structure:
Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
Activity:
Cell permeable protein kinase A inhibitor
PKI (14 - 22) amide, myristoylated, is a cell-permeable version of the protein kinase inhibitor (PKI) PKI (14-22) amide. When non-myristoylated, PKI (14-22) amide inhibits protein kinase A with a Ki of 36 nM and also inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1). Myristoylated peptides as a class may exhibit off-target activation of the funny current If in sinoatrial myocytes.
Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802 PMID: 2722799
Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197 PMID: 12947318
Liao et al (2011) Myristoylated peptides potentiate the funny current I(f) in sinoatrial myocytes. Channels 5(2) 115 doi:10.4161/chan.5.2.14195
Related areas
All cell penetrating peptides >
All kinase modulators >
All cancer research categories >
Technical Data
| Structure | Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2 |
| CAS Number | 201422-03-9 |
| Molecular Weight | 1209.5 |
| Formula | C53H100N20O12 |
| Sequence | Myr-GRTGRRNAI-NH2 |
| Modifications | Myristoyl at N terminal, amide at C terminal |
Solubility and Storage
| Solubility | Soluble in dilute acid and DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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