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Products
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PKI (5-24)
Cat. No. KS-050
Structure:
H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH
Other Names:
PKA inhibitor (5-24)
Activity:
cAMP-dependent protein kinase A (PKA) inhibitor
PKI (5-24), also known as PKA inhibitor (5-24), is a potent (Ki 2.3nM) competitive synthetic peptide inhibitor of cAMP-dependent protein kinase A (PKA) derived from the active domain of the naturally-occurring heat-stable inhibitor protein PKI. PKI (5-24) is only a very weak inhibitor of cGMP-dependent protein kinase (PKG).
Cheng et al (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J.Biol.Chem. 261 989 PMID: 3511044
Narayana et al (1997) Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry 36 4438 PMID: 9109651
Related data
Technical Data
| Structure | H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH |
| CAS Number | 99534-03-9 |
| Molecular Weight | 2222.7 |
| Formula | C94H148N32O31 |
| Sequence | TTYADFIASGRTGRRNAIHD |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
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