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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
(NahNspeNspe)4-NH2
Cat. No. PT-098
Structure:
Nah-Nspe-Nspe-Nah-Nspe-Nspe-Na-hNspe-Nspe-Nah-Nspe-Nspe-NH2
Activity:
Antibacterial and antiparasitic
Peptoids are peptide-mimicking poly-N-substituted glycines, which exhibit enhanced physiological stability and are known to have antibacterial and antiparasitic qualities. They have recently been shown to have activity against Leishmania mexicana axenic amastigotes.
Nah is the N-substituted aminohexyl peptoid monomer and Nspe is the (S)-(N-1-phenylethyl)glycine peptoid monomer
Chongsiriwatana et al (2008) Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides. Proc. Natl. Acad. Sci 105(8) 2794 DOI: 10.1073/pnas.0708254105
Zuckermann (2011) Peptoid origins. Biopolymers, 96 545 doi:10.1002/bip.21573
Sun and Zuckermann (2013) Peptoid Polymers: A Highly Designable Bioinspired Material. ACS Nano 7(6) 4715 https://doi.org/10.1021/nn4015714
Huang et al (2014) Learning from Host-Defense Peptides: Cationic, Amphipathic Peptoids with Potent Anticancer Activity. PLoS ONE 9(2) e90397. https://doi.org/10.1371/journal.pone.0090397
Eggimann et al (2015) Investigating the Anti‐leishmanial Effects of Linear Peptoids. ChemMedChem. 10 233 doi:10.1002/cmdc.201402416
Related areas
Technical Data
| Structure | Nah-Nspe-Nspe-Nah-Nspe-Nspe-Na-hNspe-Nspe-Nah-Nspe-Nspe-NH2 |
| Molecular Weight | 1930.2 |
| Formula | C112H155N17O12 |
| Sequence | Nah-Nspe-Nspe-Nah-Nspe-Nspe-Na-hNspe-Nspe-Nah-Nspe-Nspe-NH2 |
| Modifications | Nah is the N-substituted aminohexyl peptoid monomer and Nspe is the (S)-(N-1-phenylethyl)glycine peptoid monomer For more information about peptoids and their nomenclature please refer to the peptide resources page |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >90% By HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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