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SBP1
Cat. No. CV-050
Structure:
H-Ile-Glu-Glu-Gln-Ala-Lys-Thr-Phe-Leu-Asp-Lys-Phe-Asn-His-Glu-Ala-Glu-Asp-Leu-Phe-Tyr-Gln-Ser-NH2
Activity:
Binds to the SARS-CoV-2 receptor binding domain
SBP1 is a 23 amino acid fragment of the angiotensin-converting enzyme 2 (ACE2) peptidase domain (PD) α1 helix, a key domain for the interaction of ACE2 with the severe acute respiratory syndrome coronavirus receptor binding domain (SARS-CoV-2-RBD). SBP1 binds to the SARS-CoV-2-RBD with an affinity comparable with the corresponding spike protein of SARS-CoV, and can potentially block the mechanism by which SARS-CoV-2 enters into cells. SBP1 offers an opportunity for therapeutic intervention in COVID-19.
Zhang et al (2020) The first-in-class peptide binder to the SARS-CoV-2 spike protein. bioRxiv 2020.03.19.999318; doi: https://doi.org/10.1101/2020.03.19.999318
Zhang et al (2020) Investigation of ACE2 N-terminal fragments binding to SARS-CoV-2 Spike RBD. bioRxiv 2020.03.19.999318; doi: https://doi.org/10.1101/2020.03.19.999318
Related areas
All peptides >
All angiotensin converting enzyme modulators >
All antivirals >
Technical Data
| Structure | H-Ile-Glu-Glu-Gln-Ala-Lys-Thr-Phe-Leu-Asp-Lys-Phe-Asn-His-Glu-Ala-Glu-Asp-Leu-Phe-Tyr-Gln-Ser-NH2 |
| Molecular Weight | 2802.05 |
| Formula | C127H185N31O41 |
| Sequence | IEEQAKTFLDKFNHEAEDLFYQS-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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