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Mca-RPKPVE-Nval-WR-K(Dnp)-NH2
Cat. No. PS-040
Structure:
Mca-Arg-Pro-Lys-Pro-Val-Glu-Nval-Trp-Arg-Lys(Dnp)-NH2
Other Names:
Mca-RPKPVE-Nval-WRK(Dnp)-NH2 fluorogenic MMP substrate
Activity:
Fret substrate for MMP-3 and MMP-10
Mca-RPKPVE-Nval-WRK(Dnp)-NH2, also known as Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate, is an excellent substrate for MMP-3 (stromelysin 1) and MMP-10 (stromelysin 2), but not a substrate MMP-1 or MMP-2. Mca-RPKPVE-Nval-WRK(Dnp)-NH2 substrate contains a highly fluorescent 7-methoxycoumarin (Mca) group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl (Dnp) group. The cleavage site is the peptide bond between Glu and Nval (norvaline). Mca-RPKPVE-Nval-WRK(Dnp)-NH2 is also an excellent substrate for trypsin, HGF activator and factor Xa.
Gocheva et al (2006) Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 20(5) 543 PMID: 16481467
Aly et al (2009) Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med. 13(8B) 2069 PMID: 18705699
Bertran et al (2020) Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorg. Chem. 94 103365 PMID: 31676116
Related areas
All matrix metalloproteases modulators >
All fluorescent labelled peptides >
All substrate peptides >
Technical Data
| Structure | Mca-Arg-Pro-Lys-Pro-Val-Glu-Nval-Trp-Arg-Lys(Dnp)-NH2 |
| Molecular Weight | 1675.9 |
| Formula | C78H110N22O20 |
| Sequence | Mca-RPKPVEXWRK(Dnp)-NH2 |
| Modifications | 7-methoxycoumarin (Mca) at the N terminal, X is norvaline, Lysine 10 is substuted with a 2,4-dinitrophenyl (Dnp) group, and the C terminal is amidated |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Mca-RPKPVE-Nval-WR-K(Dnp)-NH2 MSDS_602bf9cd64829.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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