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Pap12-6: A host defence peptide with potent immunomodulatory activity

Published on June 5th 2024

In the fight against antimicrobial resistance, host defence peptides are promising molecules for the design of new antimicrobial agents.  In terms of their future clinical use, host defence peptides offer several advantages, based on which their application as feed additives has aroused great interest in the poultry sector.  A new article by Marton et al in PLoS one has demonstrated the immunomodulatory activity of Pap12-6, supplied by Isca, alone and in inflammatory environments evoked by lipoteichoic acid (LTA) and Poly I:C in a primary chicken hepatocyte-non-parenchymal cell co-culture.  PAP12-6 showed no cytotoxicity on hepatic cells and was able to influence the immune response, reflected by the decreased production of IL-6, IL-8, and RANTES, as well as the reduced IL-6/IL-10 ratio in Poly I:C-induced inflammation. PAP12-6 also diminished levels of extracellular H2O2 and Nrf2 when applied together with Poly I:C.  PAP12-6 is a promising starting point for the design of novel antimicrobial immunomodulatory agents for chickens.

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