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Products
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Pap12-6
Cat. No. AM-290
Structure:
H-Arg-Trp-Lys-Ile-Phe-Lys-Lys-Val-Val-Lys-Lys-Trp-NH2
Activity:
Antibacterial derived from the N-terminus of papiliocin
Pap12-6 is an antibacterial peptide derived from the 12 amino acids in the N-terminus of papiliocin, a cecropin found in swallowtail butterfly larvae. Pap12-6 possesses broad-spectrum antibacterial activity, especially against multidrug-resistant Gram-negative bacteria, acting by permeabilizing the bacterial membrane. Pap12-6 significantly reduces the secretion of NO, TNF-α, and IL-6 and also shows anti-inflammatory activity via a TLR4-mediated NF-κB signaling pathway. In a mouse sepsis model, Pap12-6 significantly improved survival, reduced bacterial growth in organs, and reduced LPS and inflammatory cytokine levels.
Kim et al (2019) Development of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis. Sci Rep. 9(1) 3817 PMID: 30846839
Son et al (2019) Effects of C-Terminal Residues of 12-Mer Peptides on Antibacterial Efficacy and Mechanism. J Microbiol Biotechnol. 29(11) 1707 PMID: 31546301
Márton et al (2024) Pap12-6: A host defense peptide with potent immunomodulatory activity in a chicken hepatic cell culture. PLoS One 19(5) e0302913 PMID: 38728358
Related data
All antimicrobial peptides >
All immunology research categories >
Technical Data
| Structure | H-Arg-Trp-Lys-Ile-Phe-Lys-Lys-Val-Val-Lys-Lys-Trp-NH2 |
| Molecular Weight | 1645.11 |
| Formula | C83H133N23O12 |
| Sequence | RWKIFKKVVKKW-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Certificate of Analysis | AM-290-1MG Pap12-6 CofA_667c2ef75a1d9.pdf |
| Safety Data Sheet | AM-290 Pap12-6 SDS_667c2edc09f6f.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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