New IDR-1002 citation

IDR-1002, a synthetic host defense peptide, is a candidate for the treatment of bacterial infections and the subsequent inflammatory response, currently relevant to the emerging issue of antimicrobial resistance in the farming sector.  In a new study, the effects of IDR-1002 were investigated on a chicken hepatocyte‒non-parenchymal cell co-culture.  IDR-1002 had complex effects on the regulation of the hepatic innate immunity,  increasing the levels of both RANTES and M-CSF and reducing concentrations of interleukin (IL)-6 and IL-10.  Pro-inflammatory cytokine release triggered by the bacterial cell wall component lipoteichoic acid (LTA) was ameliorated by IDR-1002, based on the levels of IL-6, chicken chemotactic and angiogenic factor (CXCLi2) and interferon (IFN)-γ.  Production of nuclear factor erythroid 2-related factor 2 (Nrf2), an essential transcription factor in the antioxidant defense pathway, was increased after IDR-1002 exposure, while protein carbonyl (PC) levels were also elevated.  IDR-1002 represents a promising tool in the treatment of bacterially induced inflammation in chickens.

View all antimicrobial peptides >
View all immunology research categories >