The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
IDR-1002
Cat. No. AM-320
Structure:
H-Val-Gln-Arg-Trp-Leu-Ile-Val-Trp-Arg-Ile-Arg-Lys-NH2
Other Names:
Innate defense regulator peptide 1002
Activity:
Innate defence regulator peptide
IDR-1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties which was identified from a library of bactenecin derivatives. IDR-1002 is protective against the Gram-negative bacterial pathogen Escherichia coli with chemokine induction by IDR-1002 being mediated through a Gi-coupled receptor and the PI3K, NF-kappaB, and MAPK signaling pathways. IDR-1002 suppresses in vitro inflammatory responses in murine monocyte/macrophage cells challenged with TLR4 and TLR2 agonists, and reduces airway hyperresponsiveness and inflammation in a house dust mite challenged model of airway inflammation.
Nijnik (2010) Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. 184(5) 2539 PMID: 20107187
Wu et al (2017) Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model. J Immunol. 199(10) 3592 PMID: 28993516
Piyadasa et al (2021) Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002. J Med Chem. 64(10) 6696 PMID: 33974425
Sebők et al (2023) Modulation of the immune response by the host defense peptide IDR-1002 in chicken hepatic cell culture. Sci Rep. 13(1) 14530 PMID: 37666888
Related products
All antimicrobial peptides >
All immunology research categories >
Technical Data
| Structure | H-Val-Gln-Arg-Trp-Leu-Ile-Val-Trp-Arg-Ile-Arg-Lys-NH2 |
| CAS Number | 1224095-25-3 |
| Molecular Weight | 1652.06 |
| Formula | C79H130N26O13 |
| Sequence | VQRWLIVWRIRK-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: info@abyntek.com
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: sale3@78bio.com
India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: globalbusiness1@namiki-s.co.jp
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn moreContact us
Isca Biochemicals
26 Hanover Road
Exeter
EX1 2TL
(+44) 01392 422205
info@iscabiochemicals.com
© 2026 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio