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E70K
Cat. No. IM-015
Structure:
Ac-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu-Lys-Phe-Leu-Lys-Arg-Ala-Lys-Asn-Ser-NH2
Other Names:
Peptide 2
Activity:
Inhibits CXCL8-induced neutrophil transendothelial migration
E70K, also known as peptide 2, is the C-terminal CXCL8 peptide fragment CXCL8 (54-72), with a glutamic acid (E) substituted at position 70 with lysine (K) to increase positive charge. Similarly to CXCL8 (54-72), E70K inhibits CXCL8-induced neutrophil transendothelial migration and provides a lead for further development of therapeutic inhibitors of neutrophil-mediated inflammation based on modulation of chemokine–GAG binding.
Martínez‐Burgo et al (2019), A C‐terminal CXCL 8 peptide based on chemokine–glycosaminoglycan interactions reduces neutrophil adhesion and migration during inflammation. Immunol. 157 173 PMID: 31013364
Related areas
All peptides >
All chemokine receptor modulators >
All adhesion molecule research categories >
All immunology research categories >
Technical Data
| Structure | Ac-Lys-Glu-Asn-Trp-Val-Gln-Arg-Val-Val-Glu-Lys-Phe-Leu-Lys-Arg-Ala-Lys-Asn-Ser-NH2 |
| Molecular Weight | 2400.81 |
| Formula | C108H178N34O28 |
| Sequence | Ac-KENWVQRVVEKFLKRAKNS-NH2 |
| Modifications | N terminal acetylation, C terminal amide |
Solubility and Storage
| Solubility | Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution. |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | E70K MSDS_602bbc950e2a1.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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