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Products
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CXCL9(74–103)
Cat. No. CK-040
Structure:
H-Lys-Lys-Lys-Gln-Lys-Asn-Gly-Lys-Lys-His-Gln-Lys-Lys-Lys-Val-Leu-Lys-Val-Arg-Lys-Ser-Gln-Arg-Ser-Arg-Gln-Lys-Lys-Thr-Thr-OH
Other Names:
CXCL9 peptide
Activity:
Competes with CXCL8 for GAG binding
CXCL9(74–103) is a peptide corresponding to the C-terminal amino acids of the chemokine CXCL9. CXCL9(74–103) does not signal through or act as an antagonist for CXCR3, the CXCL9 receptor, or influence the neutrophil chemotactic activity of CXCL8 in vitro, but it does display high affinity for glycosaminoglycans (GAGs), and can displace chemokines bound to GAGs. CXCL8 and CXCL9 drive leukocyte migration to inflammation sites and through this inhibition of the chemokine-GAG interaction, CXCL9(74–103) can block neutrophil migration. In vivo, CXCL9(74-103) ameliorates joint inflammation in a murine model of antigen induced arthritis, reducing neutrophil accumulation and joint and cartilage damage, and is also effective in a murine model of gout.
Vanheule et al (2015) The Positively Charged COOH-terminal Glycosaminoglycan-binding CXCL9(74-103) Peptide Inhibits CXCL8-induced Neutrophil Extravasation and Monosodium Urate Crystal-induced Gout in Mice. J Biol Chem. 290(35) 21292 PMID: 26183778
Boff (2018) The chemokine fragment CXCL9(74-103) diminishes neutrophil recruitment and joint inflammation in antigen-induced arthritis. J Leukoc Biol. 104(2) 413 PMID: 29733455
De Zutter et al (2021) The Chemokine-Based Peptide, CXCL9(74-103), Inhibits Angiogenesis by Blocking Heparan Sulfate Proteoglycan-Mediated Signaling of Multiple Endothelial Growth Factors. Cancers 13(20) 5090 PMID: 34680238
Related areas
All peptides >
All chemokine receptor modulators >
All immunology research categories >
Technical Data
| Structure | H-Lys-Lys-Lys-Gln-Lys-Asn-Gly-Lys-Lys-His-Gln-Lys-Lys-Lys-Val-Leu-Lys-Val-Arg-Lys-Ser-Gln-Arg-Ser-Arg-Gln-Lys-Lys-Thr-Thr-OH |
| Molecular Weight | 3659.29 |
| Formula | C158H295N59O40 |
| Sequence | KKKQKNGKKHQKKKVLKVRKSQRSRQKKTT |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freexe dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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