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HBP08
Cat. No. CK-020
Structure:
H-Gly-Tyr-His-Tyr-Glu-Arg-Trp-Ile-His-OH
Activity:
CXCL12/HMGB1 heterocomplex inhibitor
HBP08 is a selective inhibitor of the CXCL12/HMGB1 interaction, which binds to HMGB1 (high mobility group box1) with a Kd of 0.8 µM. HMGB1 is a nonhistone nuclear protein, which acts as a DNA chaperone,
contributing to gene transcription and DNA repair, and is released under stress conditions when it forms a heterocomplex with CXCL12. This heterocomplex acts on the chemokine receptor CXCR4, enhancing cell migration, and in some pathological
conditions, exacerbating the immune response. HBP08 disruption of this heterocomplex can diminish excessive cell influx at inflammatory sites.
Sgrignani et al (2021) Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction. J Med Chem. 64(18) 13439 PMID: 34510899
Related areas
All peptides >
All chemokine receptor modulators >
All protein-protein modulators >
All nuclear receptor modulators >
All immunology categories >
Technical Data
| Structure | H-Gly-Tyr-His-Tyr-Glu-Arg-Trp-Ile-His-OH |
| Molecular Weight | 1260.37 |
| Formula | C60H77N17O14 |
| Sequence | GYHYERWIH |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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