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Products
Pharmacology
Type
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- Custom services
- Ordering
- About Us
- Technical support
- Resources
KEMPFPKYPVEP peptide
Cat. No. DA-010
Structure:
H-Lys-Glu-Met-Pro-Phe-Pro-Lys-Tyr-Pro-Val-Glu-Pro-OH
Activity:
Improves memory performance
KEMPFPKYPVEP is a peptide identified from a screen of digested casein protein for the ability to improve spatial memory in amnesia mouse models. KEMPFPKYPVEP peptide was found to prevent scopolamine induced deficit in short term spatial memory, and also enhance long term object recognition memory in intact mice, with increased levels of dopamine and norepinephrine, but not serotonin being found in the frontal cortex. Previous epidemiological investigations have indicated that consuming dairy products can prevent cognitive decline, however only cheese fermented with fungi contains the KEMPFPKYPVEP peptide, which is found at the highest level in Camembert at 14.58-39.02 pmol per gram.
Ano et al (2019) Identification of a Novel Peptide from β-Casein That Enhances Spatial and Object Recognition Memory in Mice. J Agric Food Chem. 67(29) 8160 PMID: 31241932
Related areas
Technical Data
| Structure | H-Lys-Glu-Met-Pro-Phe-Pro-Lys-Tyr-Pro-Val-Glu-Pro-OH |
| Molecular Weight | 1460.74 |
| Formula | C70H104N14O18S |
| Sequence | KEMPFPKYPVEP |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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