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PTD2
Cat. No. HM-010
Structure:
Ac-Gly-Val-Nle-Arg-Ile-NH2
Activity:
WHSC1 inhibitor
PTD2 is a peptide derived from the histone H4 sequence surrounding residue K44 (H4K44) that acts as an inhibitor of Wolf-Hirschhorn syndrome candidate 1 (WHSC1). WHSC1 (also known as NSD2 or MMSET) is a histone 3 lysine 36 (H3K36) specific methyltransferase that is responsible for mono- and dimethylation of lysine 36 on histone H3, and is frequently deleted in the genetic disorder Wolf-Hirschhorn syndrome, and has also been implicated as a driver in a variety of haematological and solid tumours. PTD2 inhibits WHSC1 in biochemical and biophysical assays with similar micromolar potencies, but demonstrates no enzymatic inhibition against a panel of other histone methyltransferases. PTD2 is a valuable tool for in vitro assay development and validation.
Morrison et al (2018) Identification of a peptide inhibitor for the histone methyltransferase WHSC1. PLoS One 13(5) PMID: 29742153
Related data
All peptides >
All histone methyltransferase modulators >
All epigenetic research categories >
All cancer research categories >
Technical Data
| Structure | Ac-Gly-Val-Nle-Arg-Ile-NH2 |
| Molecular Weight | 597.76 |
| Formula | C27H51N9O6 |
| Sequence | Ac-GVXRI-NH2 |
| Modifications | N terminal acetyl, C terminal amide, X = Nle |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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